Ontology highlight
ABSTRACT:
SUBMITTER: Wei SC
PROVIDER: S-EPMC5591072 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Wei Spencer C SC Levine Jacob H JH Cogdill Alexandria P AP Zhao Yang Y Anang Nana-Ama A S NAS Andrews Miles C MC Sharma Padmanee P Wang Jing J Wargo Jennifer A JA Pe'er Dana D Allison James P JP
Cell 20170810 6
Immune-checkpoint blockade is able to achieve durable responses in a subset of patients; however, we lack a satisfying comprehension of the underlying mechanisms of anti-CTLA-4- and anti-PD-1-induced tumor rejection. To address these issues, we utilized mass cytometry to comprehensively profile the effects of checkpoint blockade on tumor immune infiltrates in human melanoma and murine tumor models. These analyses reveal a spectrum of tumor-infiltrating T cell populations that are highly similar ...[more]