Identification of a p53-repressed gene module in breast cancer cells.
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ABSTRACT:
SUBMITTER: Miyamoto T
PROVIDER: S-EPMC5593526 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
Identification of a p53-repressed gene module in breast cancer cells.
Miyamoto Takafumi T Tanikawa Chizu C Yodsurang Varalee V Zhang Yao-Zhong YZ Imoto Seiya S Yamaguchi Rui R Miyano Satoru S Nakagawa Hidewaki H Matsuda Koichi K
Oncotarget 20170726 34
The p53 protein is a sophisticated transcription factor that regulates dozens of target genes simultaneously in accordance with the cellular circumstances. Although considerable efforts have been made to elucidate the functions of p53-induced genes, a holistic understanding of the orchestrated signaling network repressed by p53 remains elusive. Here, we performed a systematic analysis to identify simultaneously regulated p53-repressed genes in breast cancer cells. Consequently, 28 genes were des ...[more]
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