Ontology highlight
ABSTRACT:
SUBMITTER: Caslin HL
PROVIDER: S-EPMC5593780 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Caslin Heather L HL McLeod Jamie Josephine Avila JJA Spence Andrew J AJ Qayum Amina Abdul AA Kolawole Elizabeth Motunrayo EM Taruselli Marcela T MT Paranjape Anuya A Elford Howard L HL Ryan John J JJ
Cellular immunology 20170711
While IgE is considered the primary mediator of mast cell activation, IL-33 contributes substantially in asthma, allergic rhinitis, and atopic dermatitis. To develop effective treatments for allergic disease, it is important to understand the role of therapeutic agents on IL-33 activation. We examined the effect of Didox (3,4-dihydroxybenzohydroxamic acid), an antioxidant and ribonucleotide reductase (RNR) inhibitor, on IL-33-mediated mast cell activation. Didox suppressed IL-6, IL-13, TNF, and ...[more]