Dataset Information

Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration.

ABSTRACT:

Purpose

There is growing evidence of the importance of nutrition in age-related macular degeneration (AMD), but no prospective studies have explored the impact of vitamin D. We evaluated the association between vitamin D intake and progression to advanced AMD.

Methods

Among 2146 participants (3965 eyes), 541 (777 eyes) progressed from early or intermediate AMD to advanced disease (mean follow-up: 9.4 years) based on ocular imaging. Nutrients were log transformed and calorie adjusted. Survival analysis was used to assess associations between incident advanced disease and vitamin D intake. Neovascular disease (NV) and geographic atrophy (GA) were evaluated separately. Combined effects of dietary vitamin D and calcium were assessed based on high or low consumption of each nutrient.

Results

There was a lower risk of progression to advanced AMD in the highest versus lowest quintile of dietary vitamin D intake after adjustment for demographic, behavioral, ocular, and nutritional factors (hazard ratio [HR]: 0.60; 95% confidence interval [CI]: 0.43-0.83; P trend = 0.0007). Similar results were observed for NV (HR: 0.59; 95% CI: 0.39-0.89; P trend = 0.005) but not GA (HR: 0.83; 95% CI: 0.53-1.30; P trend = 0.35). A protective effect was observed for advanced AMD among participants with high vitamin D and low calcium compared to the group with low levels for each nutrient (HR: 0.67; 95% CI: 0.50-0.88; P = 0.005). When supplement use was considered, the effect was in the protective direction but was not significant.

Conclusions

A diet rich in vitamin D may prevent or delay progression to advanced AMD, especially NV. Additional exploration is needed to elucidate the potential protective role of vitamin D and its contribution to reducing visual loss.

SUBMITTER: Merle BMJ

PROVIDER: S-EPMC5595226 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Publications

Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration.

Merle Bénédicte M J BMJ Silver Rachel E RE Rosner Bernard B Seddon Johanna M JM

Investigative ophthalmology & visual science 20170901 11

<h4>Purpose</h4>There is growing evidence of the importance of nutrition in age-related macular degeneration (AMD), but no prospective studies have explored the impact of vitamin D. We evaluated the association between vitamin D intake and progression to advanced AMD.<h4>Methods</h4>Among 2146 participants (3965 eyes), 541 (777 eyes) progressed from early or intermediate AMD to advanced disease (mean follow-up: 9.4 years) based on ocular imaging. Nutrients were log transformed and calorie adjust ...[more]

PMID: 28892825

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Dataset Information

Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration.

Purpose

Methods

Results

Conclusions

Publications

Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration.

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