Farnesol inhibits translation to limit growth and filamentation in C. albicans and S. cerevisiae.
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ABSTRACT:
SUBMITTER: Egbe NE
PROVIDER: S-EPMC5597792 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
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Farnesol inhibits translation to limit growth and filamentation in <i>C. albicans</i> and <i>S. cerevisiae</i>.
Egbe Nkechi E NE Dornelles Tawni O TO Paget Caroline M CM Castelli Lydia M LM Ashe Mark P MP
Microbial cell (Graz, Austria) 20170904 9
<i>Candida albicans</i> is a polymorphic yeast where the capacity to switch between yeast and filamentous growth is critical for pathogenicity. Farnesol is a quorum-sensing sesquiterpene alcohol that, via regulation of specific signalling and transcription components, inhibits filamentous growth in <i>Candida albicans</i>. Here we show that farnesol also inhibits translation at the initiation step in both <i>Candida albicans</i> and <i>S. cerevisiae</i>. In contrast to fusel alcohols, that targe ...[more]
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