Maternal and female fetal testosterone levels are associated with maternal age and gestational weight gain.

ABSTRACT: OBJECTIVE:Prenatal androgen exposure has been suggested to play a role in polycystic ovary syndrome. Given the limited information on what maternal characteristics influence maternal testosterone levels, and the even less explored routes by which female fetus androgen exposure would occur, the aim of this study was to investigate the impact of maternal age, BMI, weight gain, depressed mood and aromatase SNPs on testosterone levels in maternal serum and amniotic fluid of female fetuses. METHODS:Blood samples from pregnant women (n?=?216) obtained in gestational weeks 35-39, and pre-labor amniotic fluid samples from female fetuses (n?=?56), taken at planned Caesarean section or in conjunction with amniotomy for induction of labor, were analyzed. Maternal serum testosterone and amniotic fluid testosterone and cortisol were measured by tandem mass spectrometry. RESULTS:Multiparity (??=?-0.28, P?

SUBMITTER: Kallak TK 

PROVIDER: S-EPMC5597951 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature