Leucine and its transporter provide protection against cigarette smoke-induced cell death: A potential therapy for emphysema.
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ABSTRACT:
SUBMITTER: Das B
PROVIDER: S-EPMC5598113 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
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Leucine and its transporter provide protection against cigarette smoke-induced cell death: A potential therapy for emphysema.
Das Bannhi B Ray Tanusree T Panda Kaushik K KK Maiti Arnab A Sarkar Srimonti S Sil Alok K AK
Toxicology reports 20140928
Cigarette smoke (CS) is a major risk factor for emphysematous changes in the lungs and the underlying mechanism involves CS-induced cell death. In the present study we investigated the ability of nutrients to rescue CS-induced cell death. We observed that pre-treatment with excess leucine can partially rescue CS extract-induced cell death in <i>Saccharomyces cerevisiae</i> and alveolar epithelial A549 cells. Excess dietary leucine was also effective in alleviating effects of CS in guinea pig lun ...[more]
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