Ontology highlight
ABSTRACT:
SUBMITTER: Kato K
PROVIDER: S-EPMC5599168 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Kato Kosuke K Hanss Alec D AD Zemskova Marina A MA Morgan Nicole E NE Kim Marianne M Knox Kenneth S KS Lin Yong Y Lillehoj Erik P EP Kim Kwang Chul KC
Biochemical and biophysical research communications 20170816 2
Alveolar macrophages (AMs) play a critical role in the clearance of Pseudomonas aeruginosa (Pa) from the airways. However, hyper-activation of macrophages can impair bacterial clearance and contribute to morbidity and mortality. MUC1 mucin is a membrane-tethered, high molecular mass glycoprotein expressed on the apical surface of mucosal epithelial cells and some hematopoietic cells, including macrophages, where it counter-regulates inflammation. We recently reported that Pa up-regulates the exp ...[more]