Dataset Information
Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children.
Ontology highlight
ABSTRACT:
SUBMITTER: Wendel BS
PROVIDER: S-EPMC5599618 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children.
Nature communications 20170914 1
Accurately measuring antibody repertoire sequence composition in a small amount of blood is challenging yet important for understanding repertoire responses to infection and vaccination. We develop molecular identifier clustering-based immune repertoire sequencing (MIDCIRS) and use it to study age-related antibody repertoire development and diversification before and during acute malaria in infants (< 12 months old) and toddlers (12-47 months old) with 4-8 ml of blood. Here, we show this accurat ...[more]
