Ontology highlight
ABSTRACT:
SUBMITTER: Kumar R
PROVIDER: S-EPMC4321288 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Kumar Rashmi R Bach Martina P MP Mainoldi Federica F Maruya Mikako M Kishigami Satoshi S Jumaa Hassan H Wakayama Teruhiko T Kanagawa Osami O Fagarasan Sidonia S Casola Stefano S
Proceedings of the National Academy of Sciences of the United States of America 20150121 5
In mammals, VDJ recombination is responsible for the establishment of a highly diversified preimmune antibody repertoire. Acquisition of a functional Ig heavy (H) chain variable (V) gene rearrangement is thought to prevent further recombination at the IgH locus. Here, we describe VHQ52(NT); Vκgr32(NT) Ig monoclonal mice reprogrammed from the nucleus of an intestinal IgA(+) plasma cell. In VHQ52(NT) mice, IgA replaced IgM to drive early B-cell development and peripheral B-cell maturation. In VHQ5 ...[more]