Ontology highlight
ABSTRACT:
SUBMITTER: Zheng B
PROVIDER: S-EPMC5601313 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Zheng Bo B Chen Lei L Gonzalez Frank J FJ
Kidney international reports 20160805 3
Diabetic nephropathy (DN) is the major reason for end stage renal disease in the western world. Patients with DN developed more severe cardiovascular complications with worse prognosis. In spite of tight blood pressure and glucose control through applying angiotensin II receptor antagonism, angiotensin receptor inhibitors and even direct renin inhibitors, the progression and development of DN has continued to accelerate. Nuclear receptors are, with few exceptions, ligand-depended transcription f ...[more]