Ontology highlight
ABSTRACT:
SUBMITTER: Cavedo E
PROVIDER: S-EPMC5601919 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Scientific reports 20170915 1
Acetylcholinesterase inhibitors are approved drugs currently used for the treatment of Alzheimer's disease (AD) dementia. Basal forebrain cholinergic system (BFCS) atrophy is reported to precede both entorhinal cortex atrophy and memory impairment in AD, challenging the traditional model of the temporal sequence of topographical pathology associated with AD. We studied the effect of one-year Donepezil treatment on the rate of BFCS atrophy in prodromal AD patients using a double-blind, randomized ...[more]