Ontology highlight
ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC5603913 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Chen Liang L Brewer Michael D MD Guo Lili L Wang Ruoxing R Jiang Peng P Yang Xiaolu X
Cell reports 20170301 13
An adequate cellular capacity to degrade misfolded proteins is critical for cell survival and organismal health. A diminished capacity is associated with aging and neurodegenerative diseases; however, the consequences of an enhanced capacity remain undefined. Here, we report that the ability to clear misfolded proteins is increased during oncogenic transformation and is reduced upon tumor cell differentiation. The augmented capacity mitigates oxidative stress associated with oncogenic growth and ...[more]