Dataset Information

Circ-Vps41 positively modulates Syp and its overexpression improves memory ability in aging mice.

ABSTRACT:

Introduction

Age is an established risk factor for neurodegenerative disorders. Aging-related cognitive decline is a common cause of memory impairment in aging individuals, in which hippocampal synaptic plasticity and hippocampus-dependent memory formation are damaged. Circular RNAs (circRNAs) have been reported in many cognitive disorders, but their role in aging-related memory impairment is unclear.Methods: In this study, we aimed to investigate the effects of circ-Vps41 on aging-related hippocampus-dependent memory impairment and explore the potential mechanisms. Here, D-galactose was used to produce a conventional aging model resulting in memory dysfunction.

Results

Circ-Vps41 was significantly downregulated in D-galactose-induced aging in vitro and in vivo. The overexpression of circ-Vps41 could upregulate synaptophysin (Syp), thereby promoting the synaptic plasticity and alleviating cognitive impairment in aging mice. Mechanistically, we found that circ-Vps41 upregulated Syp expression by physically binding to miR-24-3p. Moreover, the miR-24-3p mimics reversed the circ-Vps41 overexpression-induced increase in Syp expression.

Discussion

Overexpression of circ-Vps41 alleviated the synaptic plasticity and memory dysfunction via the miR-24-3p/Syp axis. These findings revealed circ-Vps41 regulatory network and provided new insights into its potential mechanisms for improving aging-related learning and memory impairment.

SUBMITTER: Li Y

PROVIDER: S-EPMC9756809 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Circ-Vps41 positively modulates Syp and its overexpression improves memory ability in aging mice.

Li Yibo Y Wang Hongfang H Gao Yanjing Y Zhang Runjiao R Liu Qing Q Xie Wenmeng W Liu Ziyu Z Geng Dandan D Wang Lei L

Frontiers in molecular neuroscience 20221202

<h4>Introduction</h4>Age is an established risk factor for neurodegenerative disorders. Aging-related cognitive decline is a common cause of memory impairment in aging individuals, in which hippocampal synaptic plasticity and hippocampus-dependent memory formation are damaged. Circular RNAs (circRNAs) have been reported in many cognitive disorders, but their role in aging-related memory impairment is unclear.<b>Methods:</b> In this study, we aimed to investigate the effects of circ-Vps41 on agin ...[more]

PMID: 36533129

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Dataset Information

Circ-Vps41 positively modulates Syp and its overexpression improves memory ability in aging mice.

Introduction

Results

Discussion

Publications

Circ-Vps41 positively modulates Syp and its overexpression improves memory ability in aging mice.

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