Ontology highlight
ABSTRACT:
SUBMITTER: Froning KJ
PROVIDER: S-EPMC5606552 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Froning K J KJ Leaver-Fay A A Wu X X Phan S S Gao L L Huang F F Pustilnik A A Bacica M M Houlihan K K Chai Q Q Fitchett J R JR Hendle J J Kuhlman B B Demarest S J SJ
Protein science : a publication of the Protein Society 20170731 10
The use of bispecific antibodies (BsAbs) to treat human diseases is on the rise. Increasingly complex and powerful therapeutic mechanisms made possible by BsAbs are spurring innovation of novel BsAb formats and methods for their production. The long-lived in vivo pharmacokinetics, optimal biophysical properties and potential effector functions of natural IgG monoclonal (and monospecific) antibodies has resulted in a push to generate fully IgG BsAb formats with the same quaternary structure as mo ...[more]