Ontology highlight
ABSTRACT:
SUBMITTER: Klein C
PROVIDER: S-EPMC3502232 | biostudies-literature | 2012 Nov-Dec
REPOSITORIES: biostudies-literature
Klein Christian C Sustmann Claudio C Thomas Markus M Stubenrauch Kay K Croasdale Rebecca R Schanzer Jürgen J Brinkmann Ulrich U Kettenberger Hubert H Regula Jörg T JT Schaefer Wolfgang W
mAbs 20120827 6
The development of bispecific antibodies has attracted substantial interest, and many different formats have been described. Those specifically containing an Fc part are mostly tetravalent, such as stabilized IgG-scFv fusions or dual-variable domain (DVD) IgGs. However, although they exhibit IgG-like properties and technical developability, these formats differ in size and geometry from classical IgG antibodies. Thus, considerable efforts focus on bispecific heterodimeric IgG antibodies that mor ...[more]