A Unifying Theory of Branching Morphogenesis.
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ABSTRACT:
SUBMITTER: Hannezo E
PROVIDER: S-EPMC5610190 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
A Unifying Theory of Branching Morphogenesis.
Hannezo Edouard E Scheele Colinda L G J CLGJ Moad Mohammad M Drogo Nicholas N Heer Rakesh R Sampogna Rosemary V RV van Rheenen Jacco J Simons Benjamin D BD
Cell 20170901 1
The morphogenesis of branched organs remains a subject of abiding interest. Although much is known about the underlying signaling pathways, it remains unclear how macroscopic features of branched organs, including their size, network topology, and spatial patterning, are encoded. Here, we show that, in mouse mammary gland, kidney, and human prostate, these features can be explained quantitatively within a single unifying framework of branching and annihilating random walks. Based on quantitative ...[more]
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