Structural Basis for CD4+ T Cell Epitope Dominance in Arbo-Flavivirus Envelope Proteins: A Meta-Analysis.
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ABSTRACT:
SUBMITTER: Landry SJ
PROVIDER: S-EPMC5610399 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Structural Basis for CD4+ T Cell Epitope Dominance in Arbo-Flavivirus Envelope Proteins: A Meta-Analysis.
Landry Samuel J SJ Moss Daniel L DL Cui Da D Ferrie Ryan P RP Fullerton Mitchell L ML Wells Evan A EA Yang Lu L Zhou Nini N Dougherty Thomas T Mettu Ramgopal R RR
Viral immunology 20170614 7
A meta-analysis of CD4+ T cell epitope maps reveals clusters and gaps in envelope-protein (E protein) immunogenicity that can be explained by the likelihood of epitope processing, as determined by E protein three-dimensional structures. Differential processing may be at least partially responsible for variations in disease severity among arbo-flaviruses and points to structural features that modulate protection from disease. ...[more]
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