Ontology highlight
ABSTRACT:
SUBMITTER: Lucas-Hourani M
PROVIDER: S-EPMC5610480 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20170922 10
<i>De novo</i> pyrimidine biosynthesis is a key metabolic pathway involved in multiple biosynthetic processes. Here, we identified an original series of 3-(1<i>H</i>-indol-3-yl)-2,3-dihydro-4<i>H</i>-furo[3,2-<i>c</i>]chromen-4-one derivatives as a new class of pyrimidine biosynthesis inhibitors formed by two edge-fused polycyclic moieties. We show that identified compounds exhibit broad-spectrum antiviral activity and immunostimulatory properties, in line with recent reports linking <i>de novo< ...[more]