Ontology highlight
ABSTRACT:
SUBMITTER: Yamashita N
PROVIDER: S-EPMC5614868 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Developmental cell 20170914 6
Axonal targeting of signaling receptors is essential for neuronal responses to extracellular cues. Here, we report that retrograde signaling by target-derived nerve growth factor (NGF) is necessary for soma-to-axon transcytosis of TrkA receptors in sympathetic neurons, and we define the molecular underpinnings of this positive feedback regulation that enhances neuronal sensitivity to trophic factors. Activated TrkA receptors are retrogradely transported in signaling endosomes from distal axons t ...[more]