Ontology highlight
ABSTRACT:
SUBMITTER: Cao S
PROVIDER: S-EPMC5615338 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Cancers 20170912 9
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that has been implicated in the pathogenesis of a variety of neoplasms. As suggested by its name, ALK was first described as part of a translocation product in cases of anaplastic large-cell lymphoma, with other genetic and cytogenetic ALK mutations subsequently coming to attention in the development of many other hematologic and solid organ malignancies. ALK has now been shown to play a role in the pathogenesis of several cutaneous ...[more]