Driving better and safer HER2-specific CARs for cancer therapy.
Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC5617544 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Driving better and safer HER2-specific CARs for cancer therapy.
Liu Xianqiang X Zhang Nan N Shi Huan H
Oncotarget 20170429 37
Given the clinical efficacy of chimeric antigen receptor (CAR)-based therapy in hematological malignancies, CAR T-cell therapy for a number of solid tumors has been actively investigated. Human epidermal growth factor receptor 2 (HER2) is a well-established therapeutic target in breast, as well as other types of cancer. However, HER2 CAR T cells pose a risk of lethal toxicity including cytokine release syndrome from "on-target, off-tumor" recognition of HER2. In this review, we summarize the dev ...[more]
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