Ontology highlight
ABSTRACT:
SUBMITTER: Morello A
PROVIDER: S-EPMC4744527 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Morello Aurore A Sadelain Michel M Adusumilli Prasad S PS
Cancer discovery 20151026 2
<h4>Unlabelled</h4>Chimeric antigen receptors (CAR) are synthetic receptors that target T cells to cell-surface antigens and augment T-cell function and persistence. Mesothelin is a cell-surface antigen implicated in tumor invasion, which is highly expressed in mesothelioma and lung, pancreas, breast, ovarian, and other cancers. Its low-level expression in mesothelia, however, commands thoughtful therapeutic interventions. Encouragingly, recent clinical trials evaluating active immunization or i ...[more]