Ontology highlight
ABSTRACT:
SUBMITTER: Chen N
PROVIDER: S-EPMC5943172 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Current opinion in immunology 20180316
Uniform and strong expression of CD19, a cell surface antigen, on cells of B-cell lineage is unique to hematologic malignancies. Tumor-associated antigen (TAA) targets in solid tumors exhibit heterogeneity with regards to intensity and distribution, posing a challenge for chimeric antigen receptor (CAR) T-cell therapy. Novel CAR designs, such as dual TAA-targeted CARs, tandem CARs, and switchable CARs, in conjunction with inhibitory CARs, are being investigated as means to overcome antigen heter ...[more]