Ontology highlight
ABSTRACT:
SUBMITTER: Wu G
PROVIDER: S-EPMC5621903 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Wu Guoxin G Swanson Michael M Talla Aarthi A Graham Donald D Strizki Julie J Gorman Daniel D Barnard Richard Jo RJ Blair Wade W Søgaard Ole S OS Tolstrup Martin M Østergaard Lars L Rasmussen Thomas A TA Sekaly Rafick-Pierre RP Archin Nancie M NM Margolis David M DM Hazuda Daria J DJ Howell Bonnie J BJ
JCI insight 20170817 16
Promising therapeutic approaches for eradicating HIV include transcriptional activation of provirus from latently infected cells using latency-reversing agents (LRAs) and immune-mediated clearance to purge reservoirs. Accurate detection of cells capable of producing viral antigens and virions, and the measurement of clearance of infected cells, is essential to assessing therapeutic efficacy. Here, we apply enhanced methodology extending the sensitivity limits for the rapid detection of subfemtom ...[more]