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Immune Reconstitution Inflammatory Syndrome and Cytomegalovirus Pneumonia Case Report: Highlights and Missing Links in Classification Criteria and Standardized Treatment.


ABSTRACT: BACKGROUND:Cytomegalovirus (CMV) pulmonary involvement is rarely associated with IRIS; therefore, limited information is available. CASE PRESENTATION:Here, we describe the case of a 43-year-old HIV-infected male who developed an unusual case of IRIS after cytomegalovirus (CMV) pneumonia. Clinically there was a progressive and paradoxical worsening of respiratory distress, despite being treated for CMV after initiation with antiretroviral therapy. Chest X-ray revealed disseminated infiltrates in both lungs; chest CT-scan showed generalized lung involvement and mediastinal adenopathy. Pulmonary biopsy confirmed CMV pneumonia with the observation of typical viral inclusions on pneumocytes. CONCLUSIONS:CMV pneumonia can be associated with the development of IRIS requiring treatment with immunosuppressant's and immunomodulatory drugs.

SUBMITTER: Petarra-Del Rio S 

PROVIDER: S-EPMC5624155 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Immune Reconstitution Inflammatory Syndrome and Cytomegalovirus Pneumonia Case Report: Highlights and Missing Links in Classification Criteria and Standardized Treatment.

Petarra-Del Río Stefania S   Rodriguez-Hernandez Adrian A   Anguiano-Landa Luis L   Aguilar-Portillo Georgina G   Zavala-Trujillo Isidro I   Nava-Zavala Arnulfo Hernan AH   Zavala-Cerna Maria G MG  

Case reports in infectious diseases 20170918


<h4>Background</h4>Cytomegalovirus (CMV) pulmonary involvement is rarely associated with IRIS; therefore, limited information is available.<h4>Case presentation</h4>Here, we describe the case of a 43-year-old HIV-infected male who developed an unusual case of IRIS after cytomegalovirus (CMV) pneumonia. Clinically there was a progressive and paradoxical worsening of respiratory distress, despite being treated for CMV after initiation with antiretroviral therapy. Chest X-ray revealed disseminated  ...[more]

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