Dataset Information

Cancer drug development: The missing links.

ABSTRACT: IMPACT STATEMENT:The success rate for cancer drugs which enter into phase 1 clinical trials is utterly less. Why the vast majority of drugs fail is not understood but suggests that pre-clinical studies are not adequate for human diseases. In 1975, as per the Tufts Center for the Study of Drug Development, pharmaceutical industries expended 100 million dollars for research and development of the average FDA approved drug. By 2005, this figure had more than quadrupled, to $1.3 billion. In order to recover their high and risky investment cost, pharmaceutical companies charge more for their products. However, there exists no correlation between drug development cost and actual sale of the drug. This high drug development cost could be due to the reason that all patients might not respond to the drug. Hence, a given drug has to be tested in large number of patients to show drug benefits and obtain significant results.

SUBMITTER: Kunnumakkara AB

PROVIDER: S-EPMC6552400 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Cancer drug development: The missing links.

Kunnumakkara Ajaikumar B AB Bordoloi Devivasha D Bordoloi Devivasha D Sailo Bethsebie Lalduhsaki BL Roy Nand Kishor NK Thakur Krishan Kumar KK Banik Kishore K Shakibaei Mehdi M Gupta Subash C SC Aggarwal Bharat B BB

Experimental biology and medicine (Maywood, N.J.) 20190408 8

<h4>Impact statement</h4>The success rate for cancer drugs which enter into phase 1 clinical trials is utterly less. Why the vast majority of drugs fail is not understood but suggests that pre-clinical studies are not adequate for human diseases. In 1975, as per the Tufts Center for the Study of Drug Development, pharmaceutical industries expended 100 million dollars for research and development of the average FDA approved drug. By 2005, this figure had more than quadrupled, to $1.3 billion. In ...[more]

PMID: 30961357

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Dataset Information

Cancer drug development: The missing links.

Publications

Cancer drug development: The missing links.

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