The missing links within troponin.
Ontology highlight
ABSTRACT:
SUBMITTER: Marques MA
PROVIDER: S-EPMC6377831 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
The missing links within troponin.
Marques Mayra A MA Parvatiyar Michelle S MS Yang Wei W de Oliveira Guilherme A P GAP Pinto Jose R JR
Archives of biochemistry and biophysics 20181222
The cardiac contraction-relaxation cycle is controlled by a sophisticated set of machinery. Of particular interest, is the revelation that allosteric networks transmit effects of binding at one site to influence troponin complex dynamics and structural-mediated signaling in often distal, functional sites in the myofilament. Our recent observations provide compelling evidence that allostery can explain the function of large-scale macromolecular events. Here we elaborate on our recent findings of ...[more]
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