Ontology highlight
ABSTRACT:
SUBMITTER: Zhao W
PROVIDER: S-EPMC5624330 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20170825 35
The Curtius rearrangement is a classic, powerful method for converting carboxylic acids into protected amines, but its widespread use is impeded by safety issues (the need to handle azides). We have developed an alternative to the Curtius rearrangement that employs a copper catalyst in combination with blue-LED irradiation to achieve the decarboxylative coupling of aliphatic carboxylic acid derivatives (specifically, readily available N-hydroxyphthalimide esters) to afford protected amines under ...[more]