Ontology highlight
ABSTRACT:
SUBMITTER: Khrimian L
PROVIDER: S-EPMC5626410 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20170829 10
That osteocalcin (OCN) is necessary for hippocampal-dependent memory and to prevent anxiety-like behaviors raises novel questions. One question is to determine whether OCN is also sufficient to improve these behaviors in wild-type mice, when circulating levels of OCN decline as they do with age. Here we show that the presence of OCN is necessary for the beneficial influence of plasma from young mice when injected into older mice on memory and that peripheral delivery of OCN is sufficient to impr ...[more]