Dosing antibiotics in neonates: review of the pharmacokinetic data.
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ABSTRACT:
SUBMITTER: Rivera-Chaparro ND
PROVIDER: S-EPMC5627030 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Dosing antibiotics in neonates: review of the pharmacokinetic data.
Rivera-Chaparro Nazario D ND Cohen-Wolkowiez Michael M Greenberg Rachel G RG
Future microbiology 20170731
Antibiotics are often used in neonates despite the absence of relevant dosing information in drug labels. For neonatal dosing, clinicians must extrapolate data from studies for adults and older children, who have strikingly different physiologies. As a result, dosing extrapolation can lead to increased toxicity or efficacy failures in neonates. Driven by these differences and recent legislation mandating the study of drugs in children and neonates, an increasing number of pharmacokinetic studies ...[more]
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