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Synthesis of benzannelated sultams by intramolecular Pd-catalyzed arylation of tertiary sulfonamides.

ABSTRACT: A new and efficient approach to five- and six-membered benzannelated sultams by intramolecular C-arylation of tertiary 1-(methoxycarbonyl)methanesulfonamides under palladium catalysis is described. In case of the ?-toluenesulfonamide derivative, an unexpected formation of a 2,3-diarylindole was observed under the same conditions.

SUBMITTER: Rassadin VA

PROVIDER: S-EPMC5629375 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Synthesis of benzannelated sultams by intramolecular Pd-catalyzed arylation of tertiary sulfonamides.

Rassadin Valentin A VA Scholz Mirko M Klochkova Anastasiia A AA de Meijere Armin A Sokolov Victor V VV

Beilstein journal of organic chemistry 20170912

A new and efficient approach to five- and six-membered benzannelated sultams by intramolecular <i>C</i>-arylation of tertiary 1-(methoxycarbonyl)methanesulfonamides under palladium catalysis is described. In case of the α-toluenesulfonamide derivative, an unexpected formation of a 2,3-diarylindole was observed under the same conditions. ...[more]

PMID: 29062411

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