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Copper Catalyzed Oxidative Arylation of Tertiary Carbon Centers.

ABSTRACT: We describe herein a Cu(OTf)₂ catalyzed oxidative arylation of a tertiary carbon-containing substrate including aryl malononitriles, 3-aryl benzofuran-2-ones, and 3-aryl oxindoles. In some cases, the nitrile groups of the aryl malononitriles undergo further reactions leading to lactones or imines. These reaction conditions are applicable for a range of arenes, including phenols, anilines, anisoles, and heteroarenes. Mechanistic studies support the formation of a cationic intermediate via a two-electron oxidation.

SUBMITTER: Basnet P

PROVIDER: S-EPMC7885265 | biostudies-literature |

REPOSITORIES: biostudies-literature

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