The development of activatable lytic peptides for targeting triple negative breast cancer.
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ABSTRACT:
SUBMITTER: Zhao H
PROVIDER: S-EPMC5629628 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
The development of activatable lytic peptides for targeting triple negative breast cancer.
Zhao Hui H Qin Xuan X Yang Dan D Jiang Yanhong Y Zheng Weihao W Wang Dongyuan D Tian Yuan Y Liu Qisong Q Xu Naihan N Li Zigang Z
Cell death discovery 20170717
Cytolytic peptides are an emerging class of promising cancer therapeutics shown to overcome drug resistance. They eliminate cancer cells via disruption of the phospholipid bilayer of cell membranes, a mechanism that differentiates it from traditional treatments. However, applications of lytic peptides via systematic administration are hampered by nonspecific toxicity. Here, we describe activatable, masked lytic peptides that are conjugated with anionic peptides via a cleavable linker sensitive t ...[more]
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