Ontology highlight
ABSTRACT:
SUBMITTER: Garant JM
PROVIDER: S-EPMC5630937 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Garant Jean-Michel JM Luce Mikael J MJ Scott Michelle S MS Perreault Jean-Pierre JP
Database : the journal of biological databases and curation 20150617
G-quadruplexes (G4) are tetrahelical structures formed from planar arrangement of guanines in nucleic acids. A simple, regular motif was originally proposed to describe G4-forming sequences. More recently, however, formation of G4 was discovered to depend, at least in part, on the contextual backdrop of neighboring sequences. Prediction of G4 folding is thus becoming more challenging as G4 outlier structures, not described by the originally proposed motif, are increasingly reported. Recent obser ...[more]