DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA.
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ABSTRACT:
SUBMITTER: Gao J
PROVIDER: S-EPMC6459694 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
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DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA.
Gao Jun J Byrd Alicia K AK Zybailov Boris L BL Marecki John C JC Guderyon Michael J MJ Edwards Andrea D AD Chib Shubeena S West Kirk L KL Waldrip Zachary J ZJ Mackintosh Samuel G SG Gao Zhaofeng Z Putnam Andrea A AA Jankowsky Eckhard E Raney Kevin D KD
Chemical communications (Cambridge, England) 20190401 31
We identified 29 G-quadruplex binding proteins by affinity purification and quantitative LC-MS/MS. We demonstrated that the DEAD-box RNA helicases Dbp2, Ded1 and Mss116 preferentially bind to G-quadruplex nucleic acids in vitro and destabilize RNA quadruplexes, suggesting new potential roles for these helicases in disruption of quadruplex structures in RNA. ...[more]
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