Ontology highlight
ABSTRACT:
SUBMITTER: Marrocco J
PROVIDER: S-EPMC5634406 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Marrocco Jordan J Petty Gordon H GH Ríos Mariel B MB Gray Jason D JD Kogan Joshua F JF Waters Elizabeth M EM Schmidt Eric F EF Lee Francis S FS McEwen Bruce S BS
Nature communications 20171009 1
Males and females use distinct brain circuits to cope with similar challenges. Using RNA sequencing of ribosome-bound mRNA from hippocampal CA3 neurons, we found remarkable sex differences and discovered that female mice displayed greater gene expression activation after acute stress than males. Stress-sensitive BDNF Val66Met mice of both sexes show a pre-stressed translational phenotype in which the same genes that are activated without applied stress are also induced in wild-type mice by an ac ...[more]