Ontology highlight
ABSTRACT:
SUBMITTER: Arthurs C
PROVIDER: S-EPMC5634644 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Arthurs Callum C Murtaza Bibi Nazia BN Thomson Calum C Dickens Kerry K Henrique Rui R Patel Hitendra R H HRH Beltran Mariana M Millar Michael M Thrasivoulou Christopher C Ahmed Aamir A
PloS one 20171010 10
Few quantifiable tissue biomarkers for the diagnosis and prognosis of prostate cancer exist. Using an unbiased, quantitative approach, this study evaluates the potential of three proteins of the 40S ribosomal protein complex as putative biomarkers of malignancy in prostate cancer. Prostate tissue arrays, constructed from 82 patient samples (245 tissue cores, stage pT3a or pT3b), were stained for antibodies against three ribosomal proteins, RPS19, RPS21 and RPS24. Semi-automated Ox-DAB signal qua ...[more]