Ontology highlight
ABSTRACT:
SUBMITTER: Panda A
PROVIDER: S-EPMC7367157 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Panda Anshuman A Yadav Anupama A Yeerna Huwate H Singh Amartya A Biehl Michael M Lux Markus M Schulz Alexander A Klecha Tyler T Doniach Sebastian S Khiabanian Hossein H Ganesan Shridar S Tamayo Pablo P Bhanot Gyan G
Nucleic acids research 20200701 13
We give results from a detailed analysis of human Ribosomal Protein (RP) levels in normal and cancer samples and cell lines from large mRNA, copy number variation and ribosome profiling datasets. After normalizing total RP mRNA levels per sample, we find highly consistent tissue specific RP mRNA signatures in normal and tumor samples. Multiple RP mRNA-subtypes exist in several cancers, with significant survival and genomic differences. Some RP mRNA variations among subtypes correlate with copy n ...[more]