Ontology highlight
ABSTRACT:
SUBMITTER: Li GX
PROVIDER: S-EPMC5635418 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Li Guo-Xing GX Morales-Rivera Cristian A CA Gao Fang F Wang Yaxin Y He Gang G Liu Peng P Chen Gong G
Chemical science 20170904 10
We report a unified photoredox-catalysis strategy for both hydroxylation and amidation of tertiary and benzylic C-H bonds. Use of hydroxyl perfluorobenziodoxole (PFBl-OH) oxidant is critical for efficient tertiary C-H functionalization, likely due to the enhanced electrophilicity of the benziodoxole radical. Benzylic methylene C-H bonds can be hydroxylated or amidated using unmodified hydroxyl benziodoxole oxidant Bl-OH under similar conditions. An ionic mechanism involving nucleophilic trapping ...[more]