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Site-Selective, Remote sp³ C-H Carboxylation Enabled by the Merger of Photoredox and Nickel Catalysis.

ABSTRACT: A photoinduced carboxylation of alkyl halides with CO₂ at remote sp³ C-H sites enabled by the merger of photoredox and Ni catalysis is described. This protocol features a predictable reactivity and site selectivity that can be modulated by the ligand backbone. Preliminary studies reinforce a rationale based on a dynamic displacement of the catalyst throughout the alkyl side chain.

SUBMITTER: Sahoo B

PROVIDER: S-EPMC6773098 | biostudies-literature |

REPOSITORIES: biostudies-literature

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