Ontology highlight
ABSTRACT:
SUBMITTER: Chase AR
PROVIDER: S-EPMC5638581 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Chase Anna R AR Laudermilch Ethan E Wang Jimin J Shigematsu Hideki H Yokoyama Takeshi T Schlieker Christian C
Molecular biology of the cell 20170816 21
TorsinA is an essential AAA+ ATPase requiring LAP1 or LULL1 as cofactors. The dynamics of the Torsin/cofactor system remain poorly understood, with previous models invoking Torsin/cofactor assemblies with fixed stoichiometries. Here we demonstrate that TorsinA assembles into homotypic oligomers in the presence of ATP. Torsin variants mutated at the "back" interface disrupt homo-oligomerization but still show robust ATPase activity in the presence of its cofactors. These Torsin mutants are severe ...[more]