Ontology highlight
ABSTRACT:
SUBMITTER: Demishtein A
PROVIDER: S-EPMC5640208 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Demishtein Alik A Fraiberg Milana M Berko Dikla D Tirosh Boaz B Elazar Zvulun Z Navon Ami A
Autophagy 20170809 10
Protein homeostasis in eukaryotic cells is regulated by 2 highly conserved degradative pathways, the ubiquitin-proteasome system (UPS) and macroautophagy/autophagy. Recent studies revealed a coordinated and complementary crosstalk between these systems that becomes critical under proteostatic stress. Under physiological conditions, however, the molecular crosstalk between these 2 pathways is still far from clear. Here we describe a cellular model of proteasomal substrate accumulation due to the ...[more]