Synthesis and N-Methyl-d-aspartate (NMDA) Receptor Activity of Ketamine Metabolites.
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ABSTRACT:
SUBMITTER: Morris PJ
PROVIDER: S-EPMC5641405 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Synthesis and N-Methyl-d-aspartate (NMDA) Receptor Activity of Ketamine Metabolites.
Morris Patrick J PJ Moaddel Ruin R Zanos Panos P Moore Curtis E CE Gould Todd D TD Zarate Carlos A CA Thomas Craig J CJ
Organic letters 20170822 17
Ketamine is rapidly metabolized in the human body to a variety of metabolites, including the hydroxynorketamines. At least two hydroxynorketamines have significant antidepressant action in rodent models, with limited action against the N-methyl-d-aspartate (NMDA) receptor. The synthesis of 12 hydroxynorketamines and their binding affinity to the NMDA receptor is presented here. ...[more]
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