Ontology highlight
ABSTRACT:
SUBMITTER: Bensch F
PROVIDER: S-EPMC5642894 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Bensch Frederike F Lamberts Laetitia E LE Smeenk Michaël M MM Jorritsma-Smit Annelies A Lub-de Hooge Marjolijn N MN Terwisscha van Scheltinga Anton G T AGT de Jong Johan R JR Gietema Jourik A JA Schröder Carolien P CP Thomas Marlene M Jacob Wolfgang W Abiraj Keelara K Adessi Celine C Meneses-Lorente Georgina G James Ian I Weisser Martin M Brouwers Adrienne H AH de Vries Elisabeth G E EGE
Clinical cancer research : an official journal of the American Association for Cancer Research 20170721 20
<b>Purpose:</b> We evaluated biodistribution and tumor targeting of <sup>89</sup>Zr-lumretuzumab before and during treatment with lumretuzumab, a human epidermal growth factor receptor 3 (HER3)-targeting monoclonal antibody.<b>Experimental Design:</b> Twenty patients with histologically confirmed HER3-expressing tumors received <sup>89</sup>Zr-lumretuzumab and underwent positron emission tomography (PET). In part A, <sup>89</sup>Zr-lumretuzumab was given with additional, escalating doses of unla ...[more]