Imaging EGFR and HER3 through 89Zr-labeled MEHD7945A (Duligotuzumab).
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ABSTRACT:
SUBMITTER: McKnight BN
PROVIDER: S-EPMC5998059 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Imaging EGFR and HER3 through <sup>89</sup>Zr-labeled MEHD7945A (Duligotuzumab).
McKnight Brooke N BN Kuda-Wedagedara Akhila N W ANW Sevak Kuntal K KK Abdel-Atti Dalya D Wiesend Wendy N WN Ku Anson A Selvakumar Dakshnamurthy D Carlin Sean D SD Lewis Jason S JS Viola-Villegas Nerissa T NT
Scientific reports 20180613 1
Tumor resistance to treatment paved the way toward the development of single agent drugs that target multiple molecular signatures amplified within the malignancy. The discovered crosstalk between EGFR and HER3 as well as the role of HER3 in mediating EGFR resistance made these two receptor tyrosine kinases attractive targets. MEHD7945A or duligotuzumab is a single immunotherapy agent that dually targets both molecular signatures. In this study, a positron emission tomography (PET) companion dia ...[more]
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