Ontology highlight
ABSTRACT:
SUBMITTER: Ravandi F
PROVIDER: S-EPMC5642915 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Ravandi Farhad F Othus Megan M O'Brien Susan M SM Forman Stephen J SJ Ha Chul S CS Wong Jeffrey Y C JYC Tallman Martin S MS Paietta Elisabeth E Racevskis Janis J Uy Geoffrey L GL Horowitz Mary M Takebe Naoko N Little Richard R Borate Uma U Kebriaei Partow P Kingsbury Laura L Kantarjian Hagop M HM Radich Jerald P JP Erba Harry P HP Appelbaum Frederick R FR
Blood advances 20161201 3
This multicenter trial was conducted to determine whether the addition of dasatinib to chemotherapy followed by an allogeneic hematopoietic cell transplant (HCT) in patients with Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL) was feasible. Patients ≥ 18 and ≤ 60 years of age with newly diagnosed Ph+ ALL received up to 8 cycles of alternating hyperCVAD and high dose cytarabine and methotrexate with dasatinib. Patients with an available matched sibling or unrelated donor ...[more]