Ontology highlight
ABSTRACT:
SUBMITTER: Zonneveld R
PROVIDER: S-EPMC5647105 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Zonneveld Rens R Jongman Rianne R Juliana Amadu A Zijlmans Wilco W Plötz Frans F Molema Grietje G van Meurs Matijs M
Shock (Augusta, Ga.) 20171201 6
<h4>Purpose</h4>Vascular inflammation and leakage in sepsis is mediated by Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) and their phosphorylation of the endothelial Tie-2 receptor. This study investigates levels of Ang-1 and Ang-2 in newborns to gain insight in the vascular pathophysiology of early onset sepsis (EOS) within 72 h after birth.<h4>Methods</h4>A prospective cohort study was performed among 71 Surinamese newborns treated with antibiotics for suspected EOS and 20 control newborns ...[more]