Ontology highlight
ABSTRACT:
SUBMITTER: Wu H
PROVIDER: S-EPMC3855275 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Wu Hongtan H Xiao Yubo Y Zhang Shihao S Ji Suyuan S Wei Luyao L Fan Fuqin F Geng Jing J Tian Jing J Sun Xiufeng X Qin Funiu F Jin Changnan C Lin Jianjun J Yin Zhen-Yu ZY Zhang Ting T Luo Lianzhong L Li Yang Y Song Siyang S Lin Sheng-Cai SC Deng Xianming X Camargo Fernando F Avruch Joseph J Chen Lanfen L Zhou Dawang D
Cell reports 20130516 5
The transcriptional coactivator Yes-associated protein (YAP) plays an important role in organ-size control and tumorigenesis. However, how Yap gene expression is regulated remains unknown. This study shows that the Ets family member GABP binds to the Yap promoter and activates YAP transcription. The depletion of GABP downregulates YAP, resulting in a G1/S cell-cycle block and increased cell death, both of which are substantially rescued by reconstituting YAP. GABP can be inactivated by oxidative ...[more]