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Ruthenium-catalyzed insertion of adjacent diol carbon atoms into C-C bonds: Entry to type II polyketides.

ABSTRACT: Current catalytic processes involving carbon-carbon bond activation rely on ?-unsaturated coupling partners. Exploiting the concept of transfer hydrogenative coupling, we report a ruthenium(0)-catalyzed cycloaddition of benzocyclobutenones that functionalizes two adjacent saturated diol carbon-hydrogen bonds. These regio- and diastereoselective processes enable convergent construction of type II polyketide substructures.

SUBMITTER: Bender M

PROVIDER: S-EPMC5649382 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Ruthenium-catalyzed insertion of adjacent diol carbon atoms into C-C bonds: Entry to type II polyketides.

Bender Matthias M Turnbull Ben W H BWH Ambler Brett R BR Krische Michael J MJ

Science (New York, N.Y.) 20170801 6353

Current catalytic processes involving carbon-carbon bond activation rely on π-unsaturated coupling partners. Exploiting the concept of transfer hydrogenative coupling, we report a ruthenium(0)-catalyzed cycloaddition of benzocyclobutenones that functionalizes two adjacent saturated diol carbon-hydrogen bonds. These regio- and diastereoselective processes enable convergent construction of type II polyketide substructures. ...[more]

PMID: 28839069

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